Rinse the corned beef under cold running water to remove excess salt.
Place it in your pressure cooker.
Add the beef broth, Worcestershire sauce, garlic powder, and onion powder to the cooker.
Scatter the onion quarters, potatoes, carrot chunks, and garlic among the cabbage wedges, and place them evenly around the beef.
Pour the beer over everything.
Seal the pressure cooker and cook on high pressure for about 90 minutes.
Let the pressure release naturally for about 10 minutes before manually releasing any remaining pressure.
Transfer the beef to a cutting board, slice it against the grain, and serve with the veggies.