Season catfish fillets with Cajun seasoning on both sides to give them a flavorful kick.
In a hot skillet, melt 2 tablespoons of butter, then add seasoned catfish fillets.
Sear them for about 4-5 minutes on each side until they’re golden brown and cooked through.
In another pan, melt the remaining butter over medium heat.
Add garlic and mushrooms, cooking them until the mushrooms are soft.
Pour in the heavy cream and bring the mixture to a gentle simmer.
Add shrimp and let them cook until they’re pink and cooked through.
Finish the sauce with green onions, paprika, salt, and pepper, stirring well.
Simmer for a few more minutes until the sauce thickens slightly.
Serve the catfish topped with the luscious Opelousas sauce.