- Season catfish fillets with Cajun seasoning on both sides to give them a flavorful kick. 
- In a hot skillet, melt 2 tablespoons of butter, then add seasoned catfish fillets. 
- Sear them for about 4-5 minutes on each side until they’re golden brown and cooked through. 
- In another pan, melt the remaining butter over medium heat. 
- Add garlic and mushrooms, cooking them until the mushrooms are soft. 
- Pour in the heavy cream and bring the mixture to a gentle simmer. 
- Add shrimp and let them cook until they’re pink and cooked through. 
- Finish the sauce with green onions, paprika, salt, and pepper, stirring well. 
- Simmer for a few more minutes until the sauce thickens slightly. 
- Serve the catfish topped with the luscious Opelousas sauce.