Put the beef in the freezer for about 1 to 2 hours until it feels firm (not rock solid).
Thin slicing is way easier this way.
Slice the beef against the grain into strips around 1/8 to 1/4 inch thick.
Try to keep the pieces as even as you can so they dry at the same rate.
Mix up the soy sauce, water, brown sugar, Worcestershire, pineapple juice, liquid smoke, onion powder, garlic powder, black pepper, and Prague powder #1.
Stir until the sugar dissolves.
Toss the beef strips in the marinade, coat them well, and stash them in the fridge for at least 8 hours; 24 if you want deeper flavor.
Take the beef out, pat each strip dry with paper towels, and lay them out in a single layer on dehydrator trays or wire racks.
Dry at 160°F in a dehydrator for 4 to 6 hours, or in an oven at 170°F with the door slightly open for 3 to 5 hours.
The jerky should bend and crack just a bit without snapping.