Stick the beef in the freezer for about an hour so it’s easier to slice cleanly.
Trim off all visible fat, then slice the beef into 1/4-inch strips across the grain for that classic jerky chew.
Whisk together soy sauce, Worcestershire, vinegar, and brown sugar until the sugar dissolves.
Add onion powder, garlic powder, smoked paprika, and black pepper, mixing until it’s all blended.
Drop the beef strips into the marinade and make sure every piece gets coated.
Cover and refrigerate for 12 hours, flipping the strips once halfway through.
Pat the beef dry with paper towels before it hits the smoker.
Arrange the strips on smoker racks, leaving a little space between each piece.
Set your smoker to 165°F and toss in the applewood chips once the heat’s steady.
Smoke the jerky for 4 to 6 hours; look for strips that bend without snapping.
Let the jerky cool at room temp for about 30 minutes before storing.
Portion it into airtight bags or containers for snacking or storage.